Publikationen von unseren Experten bei MEDIAN

Lebenssituation Lebenszufriedenheit und komorbide psychische Symptomatik Alkoholabhängiger ein Jahr nach einer Entwöhnungsbehandlung.

Erscheinung: 2003 / Abstract Veranstaltungsbeitrag

Autoren: Sander W.

Veränderungen komorbider psychischer Symptomatik bei Abhängigkeitskranken im Verlauf einer Entwöhnungsbehandlung.

Erscheinung: 2002 / Abstract Veranstaltungsbeitrag

Autoren: Sander W., Rienas S.

Combined intra-operative monitorinq of hearinq by means of auditory brainstem responses (ABR) and transtympanic electrocochleography (ECochG) during surgery of intra- and extrameatal acoustic neurinomas

Erscheinung: 2001 / Acta Neurochirurgica

Autoren: Schlake HP., Milewski C., Goldbrunner R., Kindgen A., Riemann R., Helms J., Roosen K.

Intra-Operative electromyographic monitoring of extra-ocular motor nerves (Nn. III VI) in skull base surgery

Erscheinung: 2001 / Acta Neurochirurgica

Autoren: Schlake HP., Goldbrunner R., Siebert M., Behr R., Roosen K.

Reconstruction of large defects in vertebral osteomyelitis with expandable titanium cages

Erscheinung: 2008 / Acta Orthopaedica

Autoren: Robinson Y., Tschoeke S., Finke T., Kayser R., Heyde C.

Relationship between parameters of serotonin transport and antidepressant plasma levels or therapeutic response in depressive patients treated with paroxetine and amitriptyline

Erscheinung: 1992 / Acta Psychiatrica Scandinavica

Autoren: Kuhs H., Schlake HP., Rolf L. H., Rudolf G. A.

Link: https://www.ncbi.nlm.nih.gov/pubmed/1534961

Platelet 5-HT transport in depressed patients under double-blind treatment with paroxetine versus amitriptyline

Erscheinung: 1989 / Acta Psychiatrica Scandinavica

Autoren: Schlake HP., Kuhs H., Rolf L. H., Bosse T., Schuhknecht E., Rudolf G. A., Brune G.

Increased network centrality of the anterior insula in early abstinence from alcohol

Erscheinung: 2021 / Addiction Biology

Abnormal resting-state functional connectivity, as measured by functional magnetic resonance imaging (MRI), has been reported in alcohol use disorders (AUD), but findings are so far inconsistent. Here, we exploited recent developments in graph-theoretical analyses, enabling improved resolution and fine-grained representation of brain networks, to investigate functional connectivity in 35 recently detoxified alcohol dependent patients versus 34 healthy controls. Specifically, we focused on the modular organization, that is, the presence of tightly connected substructures within a network, and on the identification of brain regions responsible for network integration using an unbiased approach based on a large-scale network composed of more than 600 a priori defined nodes. We found significant reductions in global connectivity and region-specific disruption in the network topology in patients compared with controls. Specifically, the basal brain and the insular–supramarginal cortices, which form tightly coupled modules in healthy subjects, were fragmented in patients. Further, patients showed a strong increase in the centrality of the anterior insula, which exhibited stronger connectivity to distal cortical regions and weaker connectivity to the posterior insula. Anterior insula centrality, a measure of the integrative role of a region, was significantly associated with increased risk of relapse. Exploratory analysis suggests partial recovery of modular structure and insular connectivity in patients after 2 weeks. These findings support the hypothesis that, at least during the early stages of abstinence, the anterior insula may drive exaggerated integration of interoceptive states in AUD patients with possible consequences for decision making and emotional states and that functional connectivity is dynamically changing during treatment.

Autoren: Weil Georg

Link: https://doi.org/10.1111/adb.13096

Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone

Erscheinung: 2019 / Addiction Biology

During the first weeks of abstinence, alcohol craving in patients may increase or “incubate.” We hypothesize that Naltrexone (NTX) blocks this incubation effect. Here, we compared NTX effects on neural alcohol cue reactivity (CR) over the first weeks of abstinence and on long-term clinical outcomes to standard treatment. Male alcohol-dependent patients (n = 55) and healthy controls (n = 35) were enrolled. Participants underwent baseline psychometric testing and functional magnetic resonance imaging (fMRI) assessment of mesolimbic alcohol CR. Patients participated in a standard treatment program with the option of adjuvant NTX. They received another scan after 2 weeks of treatment. We found higher CR in several brain regions in patients versus healthy controls. CR significantly increased over 2 weeks in the standard treatment group (n = 13) but not in the NTX group (n = 22). NTX significantly attenuated CR in the left putamen and reduced relapse risk to heavy drinking within 3 months of treatment. Additionally, increased CR in the left putamen and its course over time predicted both NTX response and relapse risk. Carrier status for the functional OPRM1 variant rs1799971:A > G was considered but had no effect on NTX efficacy. In conclusion, NTX was most effective in patients with high CR in the left putamen. While the results from our naturalistic study await further confirmation from prospective randomized trials, they support a potential role of neural CR as a biomarker in the development of precision medicine approaches with NTX.

Autoren: Weil Georg

Link: https://doi.org/10.1111/adb.12717

Event-related potentials in HIV-infected outpatients

Erscheinung: 1991 / AIDS Research and Human Retroviruses

Autoren: Grotemeyer K. H., Husstedt I. W., Bründermann H., Busch H., Schlake HP., Zidek W.

Link: https://doi.org/10.1089/aid.1991.7.629