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Rapid Ca2+-dependent NO-production from central nervous system cells in culture measured by NO-nitrite/ozone chemoluminescenceErscheinung: 1997 / Brain research We have established simple and reliable measurement of constitutive nitric oxide (NO) synthase-dependent nitrite formation in supernatants from primary central nervous system (CNS) cells in culture using NO-ozone chemoluminescence. We found that: (1) astrocytes, endothelial cells and cerebellar granule cells produce NO upon stimulation with the calcium ionophore A23187 (1 microM); (2) application of 100 microM glutamate for 2 min results in NO-production in cerebellar granule cells and cortical neurons. NO-formation upon application of 50 mM KCl was found in cortical neurons; (3) in cultivated cerebral endothelial cells, an inducible form of NO-synthase (iNOS) is found under standard culture conditions. This induction was blocked by dexamethasone applied for at least 48 h and stimulation of constitutive NOS was detectable while iNOS was inhibited. The activity of iNOS was selectively inhibited by application of aminoguanidine for 48 h. Our results suggest that all major CNS cells implied in cerebral blood flow regulation and neurovascular coupling are capable of rapidly producing the vasodilator NO upon intracellular increases of the universal second messenger calcium. |
Fachkliniken – zwischen Kosten Kunden und KonkurrenzErscheinung: 1996 / Partner 2/96 |
Acamprosat – wie es verschrieben und eingesetzt werden könnteErscheinung: 1996 / Partner 3/96 |
Nitric oxide synthase inhibition does not affect somatosensory evoked potentials in the ratErscheinung: 1996 / Neuroscience Letters Nitric oxide synthase (NOS) inhibition reduces the regional cerebral blood flow (rCBF) responses to somatosensory stimulation. It is controversial whether this is caused by a signalling role of nitric oxide (NO) between neurons and vascular smooth muscle, or by effects of NOS inhibition on neuronal activity. We here report that more than 85% inhibition of NOS activity by topical application of the NOS inhibitor N omega-nitro-L-arginine (L-NNA) for 2 h does not affect somatosensory evoked potentials (SEPs) elicited by vibrissal deflection or electrical forepaw stimulation in choloralose anaesthetised rats equipped with a closed cranial window, whereas cerebral blood flow (CBF) responses due to these stimulation paradigms are reduced by approximately 60%. We conclude that the decrease of the regional vascular response to increased neuronal activity during NOS inhibition is not caused by a suppression of neuronal activity. |
Aus der Anfangszeit der deutschen Militärpsychiatrie - Soldaten zwischen Hysterie und HypnotismusErscheinung: 1996 / Psychiatrie und Zeitgeist |
Scintigraphic Techniques in the Diagnosis and Confirmation of Brain DeathErscheinung: 1995 / Brain Death. Developements in Neurology |
Der Hirntod als der Tod des MenschenErscheinung: 1995 / Deutsche Stiftung Organtransplantation |
Rückfall kann behandelt werdenErscheinung: 1995 / Partner 3/95 |
Das Netz immer dichter knüpfenErscheinung: 1995 / Partner 5/95 |
Viele (neue) Gründe für die SuchtErscheinung: 1994 / Johannesruf 2/1994 9-11 |