Publikationen unserer 
Experten bei MEDIAN

The Impact of Dietary Interventions on Cardiometabolic Health

Erscheinung: 2025 / Cardiovascular Diabetology

Diese Übersichtsarbeit beleuchtet die pathophysiologischen und evolutionären Grundlagen kardiometabolischer Erkrankungen und untersucht den Einfluss unterschiedlicher Ernährungsformen und Diätinterventionen auf metabolische Gesundheit und Krankheitsverlauf. Adipositas und kardiometabolische Erkrankungen zählen weltweit zu den führenden Ursachen für Morbidität und Mortalität und sind eng mit Lebensstilfaktoren wie Ernährung, Bewegungsmangel und Rauchen verknüpft.
Die Autor:innen fassen aktuelle, teils widersprüchliche wissenschaftliche Erkenntnisse zu Ernährungsstrategien zusammen und diskutieren deren Effekte auf Parameter wie Blutzucker, Lipidprofil, Insulinresistenz und Entzündungsmarker. Ziel ist es, evidenzbasierte, ausgewogene Ernährungsempfehlungen zur Prävention und Behandlung kardiometabolischer Erkrankungen zu formulieren.

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Obesity – An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances

Erscheinung: 29.9.2021 / Biomolecules

Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat absorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored. 

Keywords: obesity; diabetes mellitus; anti-obesity drugs; obesity metabolism; energy balance

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Phenotype-tissue expression and exploration (PTEE) resource facilitates the choice of tissue for RNA-seq-based clinical genetics studies

Erscheinung: 2021 / BMC Genomics

Background: RNA-seq emerges as a valuable method for clinical genetics. The transcriptome is “dynamic” and tissue-specific, but typically the probed tissues to analyze (TA) are different from the tissue of interest (TI) based on pathophysiology.

Results: We developed Phenotype-Tissue Expression and Exploration (PTEE), a tool to facilitate the decision about the most suitable TA for RNA-seq. We integrated phenotype-annotated genes, used 54 tissues from GTEx to perform correlation analyses and identify expressed genes and transcripts between TAs and TIs. We identified skeletal muscle as the most appropriate TA to inquire for cardiac arrhythmia genes and skin as a good proxy to study neurodevelopmental disorders. We also explored RNA-seq limitations and show that on-off switching of gene expression during ontogenesis or circadian rhythm can cause blind spots for RNA-seq-based analyses.

Conclusions: PTEE aids the identification of tissues suitable for RNA-seq for a given pathology to increase the success rate of diagnosis and gene discovery. PTEE is freely available at bioinf.eva.mpg.de/PTEE

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