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Mechanisms of stroke protection by physical activityErscheinung: 2003 / Annals of Neurology Regular physical activity is associated with a decrease of cerebrovascular and cardiovascular events, which may relate to enhanced endothelium-dependent vasodilation. Here, we provide evidence that physical activity protects against ischemic stroke via mechanisms related to the upregulation of endothelial nitric oxide synthase (eNOS) in the vasculature. Voluntary training on running wheels or exercise on a treadmill apparatus for 3 weeks, respectively, reduced cerebral infarct size and functional deficits, improved endothelium-dependent vasorelaxation, and augmented cerebral blood flow in wild-type mice. The neuroprotective effects of physical training were completely absent in eNOS-deficient mice, indicating that the enhanced eNOS activity by physical training was the predominant mechanism by which this modality protects against cerebral injury. Our results suggest that physical activity not only decreases stroke risk, but also provides a prophylactic treatment strategy for increasing blood flow and reducing brain injury during cerebral ischemia. |
Eating disorders (AN/BN): Short- and long-term outcome effects of inpatient cognitive behavior therapyErscheinung: 2010 / Annals of Behavioral Medicine |
Long-term outcome effects of behavior therapy with psychosomatic in-patients: A two years follow-upErscheinung: 2008 / Annals of Behavioral Medicine |
Das Fibromyalgiesyndrom (FMS) in der VerhaltensmedizinErscheinung: 2001 / Angewandte Verhaltensmedizin in der Rehabilitation |
Die stationäre verhaltensmedizinische Behandlung des dekompensierten chronischen TinnitusErscheinung: 2001 / Angewandte Verhaltensmedizin in der Rehabilitation |
Isolated Cortical Signal Increase on MR Imaging as a Frequent Lesion Pattern in Sporadic Creutzfeldt-Jakob Disease.Erscheinung: 2008 / American Journal of Neuroradiology |
Right venricular function assessed by tow-dimensional strain and tissue Doppler echocardiography in patients with pulmonary arterial hypertension and effect of vasodilator therapyErscheinung: 2006 / American Journal of Cardiology |
Pathophysiologische Aspekte der MigräneErscheinung: 1989 / Aktuelle Neuropädiatrie |
Technische Entwicklungen zur Rehabilitation der MobilitätErscheinung: 2017 / Aktuelle Neurologie |
Event-related potentials in HIV-infected outpatientsErscheinung: 1991 / AIDS Research and Human Retroviruses |