Publikationen von unseren Experten bei MEDIAN

Achtsamkeit und Emotionsregulation bei Patienten mit chronischem Tinnitus - Effekte achtsamkeitsbasierter Interventionen im stationären Setting

Erscheinung: 2008 / Praxis Verhaltenstherapie, Klinische Verhaltensmedizin und Rehabilitation

Autoren: Schulgen C., Horn J., Senft W.

Acoustic neuroma surgery as an interdisciplinary approach: a neurosurqical series of 508 patients

Erscheinung: 2000 / Journal of Neurology, Neurosurgery, and Psychiatry

Autoren: Tonn J. C., Schlake HP., Goldbrunner R., Milewski C., Helms J., Roosen K.

Link: https://www.ncbi.nlm.nih.gov/pubmed/10896686

Activation of the Glucocorticoid Receptor Rapidly Triggers Calcium-dependent Serotonin Release in vitro

Erscheinung: 2021 / CNS Neuroscience & Therapeutics

Aims: Glucocorticoids rapidly provoke serotonin (5-HT) release in vivo. We aimed to investigate molecular mechanisms of glucocorticoid receptor (GR)-triggered 5-HT release.Methods: Employing 1C11 cells to model 5-HT neurotransmission, immunofluorescence and Pearson's Correlation Coefficient were used to analyze colocalization of GR, 5-HT, vesicle membrane protein synaptotagmin 1 and vesicle dye FM4-64FX. FFN511 and FM4-64FX dyes as well as calcium imaging were used to visualize vesicular 5-HT release upon application of GR agonist dexamethasone, GR antagonist mifepristone and voltage-gated calcium channel (VGCC) inhibitors.Results: GR, 5-HT, synaptotagmin 1 and FM4-64FX showed overlapping staining patterns, with Pearson's Correlation Coefficient indicating colocalization. Similarly to potassium chloride, dexamethasone caused a release of FFN511 and uptake of FM4-64FX, indicating vesicular 5-HT release. Mifepristone, calcium depletion and inhibition of L-type VGCC significantly diminished dexamethasone-induced vesicular 5-HT release.Conclusions: In close proximity to 5-HT releasing sites, activated GR rapidly triggers L-type VGCC-dependent vesicular 5-HT release. These findings provide a better understanding of the interrelationship between glucocorticoids and 5-HT relea

Autoren: Paul N., Raymond J., Lumbreras S., Bartsch D., Weber Tillmann, Lau T

Link: https://doi.org/10.1111/cns.13634

Acute systemic vanadate poisoning presentinq as cerebrovascular ischemia with prolonqed reversible neuroloqical deficits (PRIND)

Erscheinung: 1994 / Clinical Neurology and Neurosurgery

Autoren: Schlake HP., Bertram H. P. , Husstedt I. W., Schuierer G.

Adaption: Anpassung an soziale Realitäten?

Erscheinung: 1998 / Fachbuch/Einzelpublikation

Autoren: Paar F., Verstege R.

ADHD Is Associated with a Higher Risk for Traumatic Events, Self-Reported PTSD, and a Higher Severity of PTSD Symptoms in Alcohol-Dependent Patients

Erscheinung: 2020 / European Addiction Research

Introduction:Alcohol dependence (AD) is frequently associated with attention-deficit/hyperactivity disorder (ADHD) as well as with posttraumatic stress disorder (PTSD).Objective:Aim of this study was to investigate whether in patients with AD, ADHD is associated with an increased rate of exposure to potentially traumatic events (PTEs) and PTSD, with increased PTSD severity and higher impact on daily functioning.Methods:Patients with AD were thoroughly assessed for ADHD during long-term residential treatment. Participants also completed the Posttraumatic Diagnostic Scale (PDS). The PDS is a 49-item self-report instrument that assesses exposure to different PTEs, DSM-IV criteria for PTSD, severity of PTSD, and related functional impairment.Results:Of 341 patients with AD, 66 were diagnosed with ADHD (19%). ADHD was associated with a more frequent exposure to PTEs (88 vs. 65%, p < 0.001). In patients with PTEs (n = 237), odds for PTSD were higher in ADHD versus no-ADHD patients (OR 8.9, 95% CI 3.9–20.5). Furthermore, PTSD severity and functional impairment were increased in ADHD patients. Conclusions: ADHD in patients with AD is associated with a higher frequency of PTEs and PTSD with more severe and more impairing PTSD symptoms. In alcohol-dependent patients with ADHD, regular screening for PTSD should be considered.

Autoren: Luderer M., Reinhard I., Richter A., Kiefer F., Weber Tillmann

Link: https://www.karger.com/Article/Abstract/508918

ADHS und pathologisches Glücksspiel

Erscheinung: 2007 / Beitrag im Fachbuch

Autoren: Retz W., Schmitt J., Vogelgesang Monika, Rösler M.

ADHS-Screening bei Alkoholabhängigen - Psychometrische Eigenschaften der ADHS-Selbstbeurteilungsskala (ADHS-SB) und der Wender-Utah-Rating-Scale Kurzform (WURS-k)

Erscheinung: 2019 / Der Nervenarzt

Die Aufmerksamkeitsdefizit-/ Hyperaktivitätsstörung (ADHS) ist eine häufige Komorbidität bei Patienten mit Abhängigkeitserkrankungen, die jedoch oft undiagnostiziert bleibt. ADHS-Selbstbeurteilungsfragebögen können helfen, Patienten zu identifizieren, für die eine weitere ausführliche ADHS-Diagnostik sinnvoll ist. Dies ist die erste deutsche Studie, die zwei in Deutschland häufig eingesetzte ADHS-Fragebögen (WURS-k und ADHS-SB) auf ihre Validität bei über 400 Patienten mit Alkoholabhängigkeit untersucht.

Autoren: Luderer M., Kaplan-Wickel N., Sick C., Richter A., Reinhard I., Kiefer F., Weber Tillmann

Link: https://doi.org/10.1007/s00115-019-0706-6

Adipositas bei gestörtem Essverhalten

Erscheinung: 2009 / Publikation in klinikeigenen Periodika

Autoren: Kerber C., Prösch U., Drevs B.

Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity

Erscheinung: 2015 / Neuropsychopharmacology

Autoren: Weber Tillmann, Vogt MA., Gartside S. E., Berger S. M. , Lujan R., Herrmann E., Sprengel R., Bartsch D., Gass P.

Link: https://doi.org/10.1038/npp.2014.332